Wongsawat J., Puthanakit T., Kanjanavanit S., Hansudewechakul R., Ngampiyaskul C., Kerr S. J., Ubolyam S., Suwanlerk T., Kosalaraksa P., Luesomboon W., Ngo-Giang-Huong Nicole, Chandara M., Saphonn V., Ruxrungtham K., Ananworanich J. (2010). Cd4 cell count criteria to determine when to initiate antiretroviral therapy in human immunodeficiency virus-infected children. Pediatric Infectious Disease Journal, 29 (10), p. 966-968. ISSN 0891-3668.
Titre du document
Cd4 cell count criteria to determine when to initiate antiretroviral therapy in human immunodeficiency virus-infected children
Année de publication
2010
Auteurs
Wongsawat J., Puthanakit T., Kanjanavanit S., Hansudewechakul R., Ngampiyaskul C., Kerr S. J., Ubolyam S., Suwanlerk T., Kosalaraksa P., Luesomboon W., Ngo-Giang-Huong Nicole, Chandara M., Saphonn V., Ruxrungtham K., Ananworanich J.
Source
Pediatric Infectious Disease Journal, 2010,
29 (10), p. 966-968 ISSN 0891-3668
We evaluated the validity of CD4 count against CD4% criteria of 2008 World Health Organization guideline for initiating antiretroviral therapy using the data of 446 human immunodeficiency virus-infected Asian children aged 1 to 12 years who were screened to the Pediatric Randomized of Early versus Deferred Initiation in Cambodia and Thailand study. The overall sensitivity and specificity were 34% and 98%, respectively. Using the current CD4 count criteria would globally result in 66% missed opportunity to initiate treatment in a timely fashion. Raising CD4 count thresholds should be considered to increase its sensitivity and reduce missed opportunity.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010092295]
Identifiant IRD
fdi:010092295
