%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Wongsawat, J.
%A Puthanakit, T.
%A Kanjanavanit, S.
%A Hansudewechakul, R.
%A Ngampiyaskul, C.
%A Kerr, S. J.
%A Ubolyam, S.
%A Suwanlerk, T.
%A Kosalaraksa, P.
%A Luesomboon, W.
%A Ngo-Giang-Huong, Nicole
%A Chandara, M.
%A Saphonn, V.
%A Ruxrungtham, K.
%A Ananworanich, J.
%T Cd4 cell count criteria to determine when to initiate antiretroviral therapy in human immunodeficiency virus-infected children
%D 2010
%L fdi:010092295
%G ENG
%J Pediatric Infectious Disease Journal
%@ 0891-3668
%K HIV ; CD4 ; antiretroviral treatment ; ART initiation ; WHO ; children ; Asia
%M ISI:000282069700014
%N 10
%P 966-968
%R 10.1097/INF.0b013e3181e0554c
%U https://www.documentation.ird.fr/hor/fdi:010092295
%> https://www.documentation.ird.fr/intranet/publi/2024-12/010092295.pdf
%V 29
%W Horizon (IRD)
%X We evaluated the validity of CD4 count against CD4% criteria of 2008 World Health Organization guideline for initiating antiretroviral therapy using the data of 446 human immunodeficiency virus-infected Asian children aged 1 to 12 years who were screened to the Pediatric Randomized of Early versus Deferred Initiation in Cambodia and Thailand study. The overall sensitivity and specificity were 34% and 98%, respectively. Using the current CD4 count criteria would globally result in 66% missed opportunity to initiate treatment in a timely fashion. Raising CD4 count thresholds should be considered to increase its sensitivity and reduce missed opportunity.
%$ 052 ; 050