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      <title>Cd4 cell count criteria to determine when to initiate antiretroviral therapy in human immunodeficiency virus-infected children</title>
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    <abstract>We evaluated the validity of CD4 count against CD4% criteria of 2008 World Health Organization guideline for initiating antiretroviral therapy using the data of 446 human immunodeficiency virus-infected Asian children aged 1 to 12 years who were screened to the Pediatric Randomized of Early versus Deferred Initiation in Cambodia and Thailand study. The overall sensitivity and specificity were 34% and 98%, respectively. Using the current CD4 count criteria would globally result in 66% missed opportunity to initiate treatment in a timely fashion. Raising CD4 count thresholds should be considered to increase its sensitivity and reduce missed opportunity.</abstract>
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    <subject>
      <topic>HIV</topic>
      <topic>CD4</topic>
      <topic>antiretroviral treatment</topic>
      <topic>ART initiation</topic>
      <topic>WHO</topic>
      <topic>children</topic>
      <topic>Asia</topic>
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      <titleInfo>
        <title>Pediatric Infectious Disease Journal</title>
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          <number>29</number>
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        <detail type="volume">
          <number>10</number>
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        <extent unit="pages">
          <list> 966-968</list>
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        <dateIssued>2010</dateIssued>
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      <identifier type="issn">0891-3668</identifier>
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    <identifier type="uri">https://www.documentation.ird.fr/hor/fdi:010092295</identifier>
    <identifier type="doi">10.1097/INF.0b013e3181e0554c</identifier>
    <identifier type="issn">0891-3668</identifier>
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      <recordCreationDate encoding="w3cdtf">2010-11-05</recordCreationDate>
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