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Castro I., Fabre N., Bourgeade-Delmas Sandra, Saffon N., Gandini C., Sauvain Michel, Castillo D., Bourdy Geneviève, Jullian Valérie. (2019). Structural characterization and anti-infective activity of 9,10-seco-29-norcycloartane glycosides isolated from the flowers of the Peruvian medicinal plant Cordia lutea. Journal of Natural Products, 82 (12), 3233-3241. ISSN 0163-3864
doi:10.1021/acs.jnatprod.9b00149
| Titre | Structural characterization and anti-infective activity of 9,10-seco-29-norcycloartane glycosides isolated from the flowers of the Peruvian medicinal plant Cordia lutea |
| Année de publication | 2019 |
| Type de document | Article référencé dans le Web of Science WOS:000505629000005 |
| Auteurs | Castro I., Fabre N., Bourgeade-Delmas Sandra, Saffon N., Gandini C., Sauvain Michel, Castillo D., Bourdy Geneviève, Jullian Valérie. |
| Source | Journal of Natural Products, 2019, 82 (12), p. 3233-3241. ISSN 0163-3864 |
| Résumé | Six new secocycloartane glycosides (1-6) were isolated from the ethanol extract of the flowers of Cordia lutea Lam. on the basis of bioassay-guided fractionation. Their structures were determined by the application of NMR and MS data analyses together with X-ray crystallographic analyses for compounds 1 and 2. Compounds 1-6 represent the first examples of 9,10-seco-29-norcycloartane glycosides. These compounds showed significant in vitro anti-Helicobacter pylori activity, and no activity against either Escherichia coli or Pseudomonas aeruginosa. Significant activity was observed for 5 and 6 against Staphylococcus aureus. All compounds displayed weak cytotoxicity against RAW 264.7 cells. The in vitro antileishmanial and antiplasmodial activities of 1-6 were also evaluated. |
| Plan de classement | Sciences du monde végétal [076] ; Santé : généralités [050] ; Sciences fondamentales / Techniques d'analyse et de recherche [020] |
| Descr. géo. | PEROU |
| Localisation | Fonds IRD [F B010077493] |
| Identifiant IRD | fdi:010077493 |
| Lien permanent | http://www.documentation.ird.fr/hor/fdi:010077493 |
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