Castro I., Fabre N., Bourgeade-Delmas Sandra, Saffon N., Gandini C., Sauvain Michel, Castillo D., Bourdy Geneviève, Jullian Valérie. (2019). Structural characterization and anti-infective activity of 9,10-seco-29-norcycloartane glycosides isolated from the flowers of the Peruvian medicinal plant Cordia lutea. Journal of Natural Products, 82 (12), 3233-3241. ISSN 0163-3864.
Titre du document
Structural characterization and anti-infective activity of 9,10-seco-29-norcycloartane glycosides isolated from the flowers of the Peruvian medicinal plant Cordia lutea
Castro I., Fabre N., Bourgeade-Delmas Sandra, Saffon N., Gandini C., Sauvain Michel, Castillo D., Bourdy Geneviève, Jullian Valérie
Source
Journal of Natural Products, 2019,
82 (12), 3233-3241 ISSN 0163-3864
Six new secocycloartane glycosides (1-6) were isolated from the ethanol extract of the flowers of Cordia lutea Lam. on the basis of bioassay-guided fractionation. Their structures were determined by the application of NMR and MS data analyses together with X-ray crystallographic analyses for compounds 1 and 2. Compounds 1-6 represent the first examples of 9,10-seco-29-norcycloartane glycosides. These compounds showed significant in vitro anti-Helicobacter pylori activity, and no activity against either Escherichia coli or Pseudomonas aeruginosa. Significant activity was observed for 5 and 6 against Staphylococcus aureus. All compounds displayed weak cytotoxicity against RAW 264.7 cells. The in vitro antileishmanial and antiplasmodial activities of 1-6 were also evaluated.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
;
Sciences du monde végétal [076]
