Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Journal of Natural Products 3233-3241 PEROU 2019 fdi:010077493 ENG Journal of Natural Products 0163-3864 ISI:000505629000005 12 10.1021/acs.jnatprod.9b00149 https://www.documentation.ird.fr/hor/fdi:010077493 https://www.documentation.ird.fr/intranet/publi/2020/01/010077493.pdf 82 Horizon (IRD) Six new secocycloartane glycosides (1-6) were isolated from the ethanol extract of the flowers of Cordia lutea Lam. on the basis of bioassay-guided fractionation. Their structures were determined by the application of NMR and MS data analyses together with X-ray crystallographic analyses for compounds 1 and 2. Compounds 1-6 represent the first examples of 9,10-seco-29-norcycloartane glycosides. These compounds showed significant in vitro anti-Helicobacter pylori activity, and no activity against either Escherichia coli or Pseudomonas aeruginosa. Significant activity was observed for 5 and 6 against Staphylococcus aureus. All compounds displayed weak cytotoxicity against RAW 264.7 cells. The in vitro antileishmanial and antiplasmodial activities of 1-6 were also evaluated. 076 ; 050 ; 020 UR152 Pérou