%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Castro, I.
%A Fabre, N.
%A Bourgeade-Delmas, Sandra
%A Saffon, N.
%A Gandini, C.
%A Sauvain, Michel
%A Castillo, D.
%A Bourdy, Geneviève
%A Jullian, Valérie
%T Structural characterization and anti-infective activity of 9,10-seco-29-norcycloartane glycosides isolated from the flowers of the Peruvian medicinal plant Cordia lutea
%D 2019
%L fdi:010077493
%G ENG
%J Journal of Natural Products
%@ 0163-3864
%K PEROU
%M ISI:000505629000005
%N 12
%P 3233-3241
%R 10.1021/acs.jnatprod.9b00149
%U https://www.documentation.ird.fr/hor/fdi:010077493
%> https://www.documentation.ird.fr/intranet/publi/2020/01/010077493.pdf
%V 82
%W Horizon (IRD)
%X Six new secocycloartane glycosides (1-6) were isolated from the ethanol extract of the flowers of Cordia lutea Lam. on the basis of bioassay-guided fractionation. Their structures were determined by the application of NMR and MS data analyses together with X-ray crystallographic analyses for compounds 1 and 2. Compounds 1-6 represent the first examples of 9,10-seco-29-norcycloartane glycosides. These compounds showed significant in vitro anti-Helicobacter pylori activity, and no activity against either Escherichia coli or Pseudomonas aeruginosa. Significant activity was observed for 5 and 6 against Staphylococcus aureus. All compounds displayed weak cytotoxicity against RAW 264.7 cells. The in vitro antileishmanial and antiplasmodial activities of 1-6 were also evaluated.
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