Castro I. auteur aut IRD Fabre N. auteur aut IRD Bourgeade-Delmas Sandra auteur aut IRD Saffon N. auteur aut IRD Gandini C. auteur aut IRD Sauvain Michel auteur aut IRD Castillo D. auteur aut IRD Bourdy Geneviève auteur aut IRD Jullian Valérie auteur aut IRD text journalArticle eng text/pdf born digital access Six new secocycloartane glycosides (1-6) were isolated from the ethanol extract of the flowers of Cordia lutea Lam. on the basis of bioassay-guided fractionation. Their structures were determined by the application of NMR and MS data analyses together with X-ray crystallographic analyses for compounds 1 and 2. Compounds 1-6 represent the first examples of 9,10-seco-29-norcycloartane glycosides. These compounds showed significant in vitro anti-Helicobacter pylori activity, and no activity against either Escherichia coli or Pseudomonas aeruginosa. Significant activity was observed for 5 and 6 against Staphylococcus aureus. All compounds displayed weak cytotoxicity against RAW 264.7 cells. The in vitro antileishmanial and antiplasmodial activities of 1-6 were also evaluated. specialized PEROU 076 050 020 82 12 3233-3241 2019 0163-3864 https://www.documentation.ird.fr/hor/fdi:010077493 10.1021/acs.jnatprod.9b00149 0163-3864 [F B010077493] https://www.documentation.ird.fr/hor/fdi:010077493 https://www.documentation.ird.fr/intranet/publi/2020/01/010077493.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2020-02-05 2025-02-24 fdi:010077493 fre