@article{fdi:010077493, title = {{S}tructural characterization and anti-infective activity of 9,10-seco-29-norcycloartane glycosides isolated from the flowers of the {P}eruvian medicinal plant {C}ordia lutea}, author = {{C}astro, {I}. and {F}abre, {N}. and {B}ourgeade-{D}elmas, {S}andra and {S}affon, {N}. and {G}andini, {C}. and {S}auvain, {M}ichel and {C}astillo, {D}. and {B}ourdy, {G}enevi{\`e}ve and {J}ullian, {V}al{\'e}rie}, editor = {}, language = {{ENG}}, abstract = {{S}ix new secocycloartane glycosides (1-6) were isolated from the ethanol extract of the flowers of {C}ordia lutea {L}am. on the basis of bioassay-guided fractionation. {T}heir structures were determined by the application of {NMR} and {MS} data analyses together with {X}-ray crystallographic analyses for compounds 1 and 2. {C}ompounds 1-6 represent the first examples of 9,10-seco-29-norcycloartane glycosides. {T}hese compounds showed significant in vitro anti-{H}elicobacter pylori activity, and no activity against either {E}scherichia coli or {P}seudomonas aeruginosa. {S}ignificant activity was observed for 5 and 6 against {S}taphylococcus aureus. {A}ll compounds displayed weak cytotoxicity against {RAW} 264.7 cells. {T}he in vitro antileishmanial and antiplasmodial activities of 1-6 were also evaluated.}, keywords = {{PEROU}}, booktitle = {}, journal = {{J}ournal of {N}atural {P}roducts}, volume = {82}, numero = {12}, pages = {3233--3241}, ISSN = {0163-3864}, year = {2019}, DOI = {10.1021/acs.jnatprod.9b00149}, URL = {https://www.documentation.ird.fr/hor/fdi:010077493}, }