Tuveri R., Perret J.L., Delaporte Eric, Nguemby-Mbina C., Revault d'Allones L., Henzel D., Faivre D., Scarpa B., Contu P., Colombo M., Thiers V., Bréchot C., Larouze B. (2000). Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, Equatorial Africa. American Journal of Tropical Medicine and Hygiene, 63 (3,4), p. 192-198. ISSN 0002-9637.
Titre du document
Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, Equatorial Africa
Année de publication
2000
Auteurs
Tuveri R., Perret J.L., Delaporte Eric, Nguemby-Mbina C., Revault d'Allones L., Henzel D., Faivre D., Scarpa B., Contu P., Colombo M., Thiers V., Bréchot C., Larouze B.
Source
American Journal of Tropical Medicine and Hygiene, 2000,
63 (3,4), p. 192-198 ISSN 0002-9637
The distribution of Hepatitis GB-C/HG (GB-C/HG) and TT viruses (TTV) infections was investigated in selected populations from Gabon using Polymerase Chain Reaction (PCR) and Enzyme Linked Immunosorbent Assay (ELISA) for anti-Envelop 2 (anti-E2) GBV-C/HGV RNA positive (+) and 32 of 81 (39.5%) anti-E2 + versus 8 of 39 (20.5%) TTV DNA +. For tuberculosis patients, the figures were 11.5% (4/35) and 0%. A study of hepatocellular carcinoma cases (n = 27) versus controls (n = 66) did not show significant differences for GBV-C/HGV RNA (10.7% versus 12.1%) and TTV DNA (44.4% versus 30.3%). According to phylogenetic analysis, the 15 GBV-C/HGV strains investigated clustered in group 1, the most common in sub-Saharan Africa whereas TTV sequences (n = 4) mostly clustered in genotypes G1 and one close to genotype G3. In the Gabonese populations investigated, GBV-C/HGV and TTV infections were highly endemic. These data are consistent with the low pathogenicity of these agents. (Résumé d'auteur)
Plan de classement
Maladies virales (sauf arbovirus) [052MALTRA01]
Descripteurs
MALADIE ; EPIDEMIE ; VIRUS ; INFECTION ; PREVALENCE ; DISTRIBUTION ; ANALYSE GENETIQUE ; METHODE D'ANALYSE ; TECHNIQUE PCR ; TEST ELISA ; PHYLOGENIE ; ETUDE EXPERIMENTALE ; ETUDE COMPARATIVE ; HEPATITE ; TUBERCULOSE
Description Géographique
GABON ; LIBREVILLE
Localisation
Fonds IRD [F B010025991] ;
Montpellier (Centre IRD)
Identifiant IRD
fdi:010025991
