%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Tuveri, R.
%A Perret, J.L.
%A Delaporte, Eric
%A Nguemby-Mbina, C.
%A Revault d'Allones, L.
%A Henzel, D.
%A Faivre, D.
%A Scarpa, B.
%A Contu, P.
%A Colombo, M.
%A Thiers, V.
%A Bréchot, C.
%A Larouze, B.
%T Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, Equatorial Africa
%D 2000
%L fdi:010025991
%G ENG
%J American Journal of Tropical Medicine and Hygiene
%@ 0002-9637
%K MALADIE ; EPIDEMIE ; VIRUS ; INFECTION ; PREVALENCE ; DISTRIBUTION ; ANALYSE GENETIQUE ; METHODE D'ANALYSE ; TECHNIQUE PCR ; TEST ELISA ; PHYLOGENIE ; ETUDE EXPERIMENTALE ; ETUDE COMPARATIVE
%K HEPATITE ; TUBERCULOSE
%K GABON ; LIBREVILLE
%K FRANCEVILLE
%N 3,4
%P 192-198
%U https://www.documentation.ird.fr/hor/fdi:010025991
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_59-60/010025991.pdf
%V 63
%W Horizon (IRD)
%X The distribution of Hepatitis GB-C/HG (GB-C/HG) and TT viruses (TTV) infections was investigated in selected populations from Gabon using Polymerase Chain Reaction (PCR) and Enzyme Linked Immunosorbent Assay (ELISA) for anti-Envelop 2 (anti-E2) GBV-C/HGV RNA positive (+) and 32 of 81 (39.5%) anti-E2 + versus 8 of 39 (20.5%) TTV DNA +. For tuberculosis patients, the figures were 11.5% (4/35) and 0%. A study of hepatocellular carcinoma cases (n = 27) versus controls (n = 66) did not show significant differences for GBV-C/HGV RNA (10.7% versus 12.1%) and TTV DNA (44.4% versus 30.3%). According to phylogenetic analysis, the 15 GBV-C/HGV strains investigated clustered in group 1, the most common in sub-Saharan Africa whereas TTV sequences (n = 4) mostly clustered in genotypes G1 and one close to genotype G3. In the Gabonese populations investigated, GBV-C/HGV and TTV infections were highly endemic. These data are consistent with the low pathogenicity of these agents. (Résumé d'auteur)
%$ 052MALTRA01