Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, Equatorial Africa Tuveri, R. Perret, J.L. /Delaporte, Eric Nguemby-Mbina, C. Revault d'Allones, L. Henzel, D. Faivre, D. Scarpa, B. Contu, P. Colombo, M. Thiers, V. Bréchot, C. Larouze, B. MALADIE EPIDEMIE VIRUS INFECTION PREVALENCE DISTRIBUTION ANALYSE GENETIQUE METHODE D'ANALYSE TECHNIQUE PCR TEST ELISA PHYLOGENIE ETUDE EXPERIMENTALE ETUDE COMPARATIVE HEPATITE TUBERCULOSE The distribution of Hepatitis GB-C/HG (GB-C/HG) and TT viruses (TTV) infections was investigated in selected populations from Gabon using Polymerase Chain Reaction (PCR) and Enzyme Linked Immunosorbent Assay (ELISA) for anti-Envelop 2 (anti-E2) GBV-C/HGV RNA positive (+) and 32 of 81 (39.5%) anti-E2 + versus 8 of 39 (20.5%) TTV DNA +. For tuberculosis patients, the figures were 11.5% (4/35) and 0%. A study of hepatocellular carcinoma cases (n = 27) versus controls (n = 66) did not show significant differences for GBV-C/HGV RNA (10.7% versus 12.1%) and TTV DNA (44.4% versus 30.3%). According to phylogenetic analysis, the 15 GBV-C/HGV strains investigated clustered in group 1, the most common in sub-Saharan Africa whereas TTV sequences (n = 4) mostly clustered in genotypes G1 and one close to genotype G3. In the Gabonese populations investigated, GBV-C/HGV and TTV infections were highly endemic. These data are consistent with the low pathogenicity of these agents. (Résumé d'auteur) 2000 text https://www.documentation.ird.fr/hor/fdi:010025991 fdi:010025991 Tuveri R., Perret J.L., Delaporte Eric, Nguemby-Mbina C., Revault d'Allones L., Henzel D., Faivre D., Scarpa B., Contu P., Colombo M., Thiers V., Bréchot C., Larouze B.. Prevalence and genetic variants of hepatitis GB-C/HG and TT viruses in Gabon, Equatorial Africa. 2000, 63 (3,4), 192-198 EN GABON LIBREVILLE