Tuveri R. auteur aut IRD Perret J.L. auteur aut IRD Delaporte Eric auteur aut IRD Nguemby-Mbina C. auteur aut IRD Revault d'Allones L. auteur aut IRD Henzel D. auteur aut IRD Faivre D. auteur aut IRD Scarpa B. auteur aut IRD Contu P. auteur aut IRD Colombo M. auteur aut IRD Thiers V. auteur aut IRD Bréchot C. auteur aut IRD Larouze B. auteur aut IRD text journalArticle eng text/pdf reformatted digital access The distribution of Hepatitis GB-C/HG (GB-C/HG) and TT viruses (TTV) infections was investigated in selected populations from Gabon using Polymerase Chain Reaction (PCR) and Enzyme Linked Immunosorbent Assay (ELISA) for anti-Envelop 2 (anti-E2) GBV-C/HGV RNA positive (+) and 32 of 81 (39.5%) anti-E2 + versus 8 of 39 (20.5%) TTV DNA +. For tuberculosis patients, the figures were 11.5% (4/35) and 0%. A study of hepatocellular carcinoma cases (n = 27) versus controls (n = 66) did not show significant differences for GBV-C/HGV RNA (10.7% versus 12.1%) and TTV DNA (44.4% versus 30.3%). According to phylogenetic analysis, the 15 GBV-C/HGV strains investigated clustered in group 1, the most common in sub-Saharan Africa whereas TTV sequences (n = 4) mostly clustered in genotypes G1 and one close to genotype G3. In the Gabonese populations investigated, GBV-C/HGV and TTV infections were highly endemic. These data are consistent with the low pathogenicity of these agents. (Résumé d'auteur) specialized MALADIE EPIDEMIE VIRUS INFECTION PREVALENCE DISTRIBUTION ANALYSE GENETIQUE METHODE D'ANALYSE TECHNIQUE PCR TEST ELISA PHYLOGENIE ETUDE EXPERIMENTALE ETUDE COMPARATIVE HEPATITE TUBERCULOSE GABON LIBREVILLE 052MALTRA01 63 3,4 192-198 2000 0002-9637 https://www.documentation.ird.fr/hor/fdi:010025991 0002-9637 [F B010025991] https://www.documentation.ird.fr/hor/fdi:010025991 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_59-60/010025991.pdf IRD - Base Horizon / Pleins textes 2001-08-21 2018-08-17 fdi:010025991 fre