Horizon 1 1 17 ACLN : Articles dans des revues avec comité de lecture non répertoriées par l'AERES American Journal of Tropical Medicine and Hygiene 192-198 MALADIE EPIDEMIE VIRUS INFECTION PREVALENCE DISTRIBUTION ANALYSE GENETIQUE METHODE D'ANALYSE TECHNIQUE PCR TEST ELISA PHYLOGENIE ETUDE EXPERIMENTALE ETUDE COMPARATIVE HEPATITE TUBERCULOSE GABON LIBREVILLE FRANCEVILLE 2000 fdi:010025991 ENG American Journal of Tropical Medicine and Hygiene 0002-9637 3,4 https://www.documentation.ird.fr/hor/fdi:010025991 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_59-60/010025991.pdf 63 Horizon (IRD) The distribution of Hepatitis GB-C/HG (GB-C/HG) and TT viruses (TTV) infections was investigated in selected populations from Gabon using Polymerase Chain Reaction (PCR) and Enzyme Linked Immunosorbent Assay (ELISA) for anti-Envelop 2 (anti-E2) GBV-C/HGV RNA positive (+) and 32 of 81 (39.5%) anti-E2 + versus 8 of 39 (20.5%) TTV DNA +. For tuberculosis patients, the figures were 11.5% (4/35) and 0%. A study of hepatocellular carcinoma cases (n = 27) versus controls (n = 66) did not show significant differences for GBV-C/HGV RNA (10.7% versus 12.1%) and TTV DNA (44.4% versus 30.3%). According to phylogenetic analysis, the 15 GBV-C/HGV strains investigated clustered in group 1, the most common in sub-Saharan Africa whereas TTV sequences (n = 4) mostly clustered in genotypes G1 and one close to genotype G3. In the Gabonese populations investigated, GBV-C/HGV and TTV infections were highly endemic. These data are consistent with the low pathogenicity of these agents. (Résumé d'auteur) 052MALTRA01