Publications des scientifiques de l'IRD

Selinger Christian, Rahmoun M., Murall C. L., Bernat C., Boue V., Bonneau M., Graf C., Grasset S., Groc S., Reynes J., Hirtz C., Jacobs N., Alizon S. (2021). Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection. Immunologic Research, [Early access], [9 p.]. ISSN 0257-277X.

Titre du document
Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection
Année de publication
2021
Type de document
Article référencé dans le Web of Science WOS:000646493500001
Auteurs
Selinger Christian, Rahmoun M., Murall C. L., Bernat C., Boue V., Bonneau M., Graf C., Grasset S., Groc S., Reynes J., Hirtz C., Jacobs N., Alizon S.
Source
Immunologic Research, 2021, [Early access], [9 p.] ISSN 0257-277X
Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority of HPV infections persist. To better characterize the immuno-modulatory impact of early HPV infections, we measured changes in a panel of 20 cytokines in cervicovaginal samples collected from young women who were tested for HPV and self-reported for genital inflammation and infection symptoms. Multi-factor statistical analyses revealed that increased IL-1Alpha and IL-12/IL-23p40 concentrations were associated with HPV infection and that macrophage inflammatory proteins were associated in particular with high-risk HPV infections. ClinicalTrials.gov identifier NCT02946346
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
FRANCE
Localisation
Fonds IRD [F B010081385]
Identifiant IRD
fdi:010081385
 Demander le PDF  DOI  HAL
Contact