Selinger Christian auteur aut IRD Rahmoun M. auteur aut IRD Murall C. L. auteur aut IRD Bernat C. auteur aut IRD Boue V. auteur aut IRD Bonneau M. auteur aut IRD Graf C. auteur aut IRD Grasset S. auteur aut IRD Groc S. auteur aut IRD Reynes J. auteur aut IRD Hirtz C. auteur aut IRD Jacobs N. auteur aut IRD Alizon S. auteur aut IRD text journalArticle eng text/pdf born digital access Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority of HPV infections persist. To better characterize the immuno-modulatory impact of early HPV infections, we measured changes in a panel of 20 cytokines in cervicovaginal samples collected from young women who were tested for HPV and self-reported for genital inflammation and infection symptoms. Multi-factor statistical analyses revealed that increased IL-1Alpha and IL-12/IL-23p40 concentrations were associated with HPV infection and that macrophage inflammatory proteins were associated in particular with high-risk HPV infections. ClinicalTrials.gov identifier NCT02946346 specialized Human papillomavirus Cytokines Natural history Mucosal immunity FRANCE 050 052 69 3 255-263 2021 0257-277X https://www.documentation.ird.fr/hor/fdi:010081385 10.1007/s12026-021-09196-2 0257-277X [F B010081385] https://www.documentation.ird.fr/hor/fdi:010081385 https://www.documentation.ird.fr/intranet/publi/2021-06/010081385.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2021-06-15 2025-10-07 fdi:010081385 fre