%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Selinger, Christian
%A Rahmoun, M.
%A Murall, C. L.
%A Bernat, C.
%A Boue, V.
%A Bonneau, M.
%A Graf, C.
%A Grasset, S.
%A Groc, S.
%A Reynes, J.
%A Hirtz, C.
%A Jacobs, N.
%A Alizon, S.
%T Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection
%D 2021
%L fdi:010081385
%G ENG
%J Immunologic Research
%@ 0257-277X
%K Human papillomavirus ; Cytokines ; Natural history ; Mucosal immunity
%K FRANCE
%K MONTPELLIER
%M ISI:000646493500001
%P [9 ]
%R 10.1007/s12026-021-09196-2
%U https://www.documentation.ird.fr/hor/fdi:010081385
%> https://www.documentation.ird.fr/intranet/publi/2021-06/010081385.pdf
%V [Early access]
%W Horizon (IRD)
%X Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority of HPV infections persist. To better characterize the immuno-modulatory impact of early HPV infections, we measured changes in a panel of 20 cytokines in cervicovaginal samples collected from young women who were tested for HPV and self-reported for genital inflammation and infection symptoms. Multi-factor statistical analyses revealed that increased IL-1Alpha and IL-12/IL-23p40 concentrations were associated with HPV infection and that macrophage inflammatory proteins were associated in particular with high-risk HPV infections. ClinicalTrials.gov identifier NCT02946346
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