Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection Immunologic Research 255-263 Human papillomavirus Cytokines Natural history Mucosal immunity FRANCE MONTPELLIER 2021 fdi:010081385 ENG Immunologic Research 0257-277X ISI:000646493500001 3 10.1007/s12026-021-09196-2 https://www.documentation.ird.fr/hor/fdi:010081385 https://www.documentation.ird.fr/intranet/publi/2021-06/010081385.pdf 69 Horizon (IRD) Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority of HPV infections persist. To better characterize the immuno-modulatory impact of early HPV infections, we measured changes in a panel of 20 cytokines in cervicovaginal samples collected from young women who were tested for HPV and self-reported for genital inflammation and infection symptoms. Multi-factor statistical analyses revealed that increased IL-1Alpha and IL-12/IL-23p40 concentrations were associated with HPV infection and that macrophage inflammatory proteins were associated in particular with high-risk HPV infections. ClinicalTrials.gov identifier NCT02946346 050 ; 052 UR224