Publications des scientifiques de l'IRD

Garavito G., Bertani Stéphane, Quiliano M., Valentin A., Aldana I., Deharo Eric. (2012). The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine. Memorias do Instituto Oswaldo Cruz, 107 (6), p. 820-823. ISSN 0074-0276.

Titre du document
The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
Année de publication
2012
Type de document
Article référencé dans le Web of Science WOS:000308943900019
Auteurs
Garavito G., Bertani Stéphane, Quiliano M., Valentin A., Aldana I., Deharo Eric
Source
Memorias do Instituto Oswaldo Cruz, 2012, 107 (6), p. 820-823 ISSN 0074-0276
The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010057237]
Identifiant IRD
fdi:010057237
Contact