@article{fdi:010057237,
  title = {{T}he in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine},
  author = {{G}aravito, {G}. and {B}ertani, {S}t{\'e}phane and {Q}uiliano, {M}. and {V}alentin, {A}. and {A}ldana, {I}. and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he effectiveness of methylene blue ({MB}) combined with pyrimethamine ({PYR}), chloroquine ({CQ}) or quinine ({Q}) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, {P}lasmodium berghei. {A} marked potentiation was observed when {MB} was administered at a non-curative dose of 15 mg/kg/day in combination with {PYR} (0.19 mg/kg/day) or {Q} (25 mg/kg/day). {N}o synergy was found between {MB} (15 mg/{K}g) and {CQ} (0.75 mg/{K}g). {O}ur results suggest that the combination of {MB} with {PYR} or {Q} may improve the efficacy of these currently used antimalarial drugs.},
  keywords = {antimalarials ; methylene blue ; drug combination},
  booktitle = {},
  journal = {{M}emorias do {I}nstituto {O}swaldo {C}ruz},
  volume = {107},
  numero = {6},
  pages = {820--823},
  ISSN = {0074-0276},
  year = {2012},
  URL = {https://www.documentation.ird.fr/hor/fdi:010057237},
}