Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Memorias do Instituto Oswaldo Cruz 820-823 antimalarials methylene blue drug combination 2012 fdi:010057237 ENG Memorias do Instituto Oswaldo Cruz 0074-0276 ISI:000308943900019 6 https://www.documentation.ird.fr/hor/fdi:010057237 https://www.documentation.ird.fr/intranet/publi/2012/10/010057237.pdf 107 Horizon (IRD) The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs. 052 UR152 Colombie / Pérou