%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Garavito, G.
%A Bertani, Stéphane
%A Quiliano, M.
%A Valentin, A.
%A Aldana, I.
%A Deharo, Eric
%T The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
%D 2012
%L fdi:010057237
%G ENG
%J Memorias do Instituto Oswaldo Cruz
%@ 0074-0276
%K antimalarials ; methylene blue ; drug combination
%M ISI:000308943900019
%N 6
%P 820-823
%U https://www.documentation.ird.fr/hor/fdi:010057237
%> https://www.documentation.ird.fr/intranet/publi/2012/10/010057237.pdf
%V 107
%W Horizon (IRD)
%X The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.
%$ 052