The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine Garavito, G. /Bertani, Stéphane Quiliano, M. Valentin, A. Aldana, I. /Deharo, Eric antimalarials methylene blue drug combination The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs. 2012 text https://www.documentation.ird.fr/hor/fdi:010057237 fdi:010057237 Garavito G., Bertani Stéphane, Quiliano M., Valentin A., Aldana I., Deharo Eric. The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine. 2012, 107 (6), 820-823 EN