Kamgno J., Pion Sebastien D., Mackenzie C. D., Thylefors B., Boussinesq Michel. (2009). Loa loa microfilarial periodicity in ivermectin-treated patients : comparison between those developing and those free of serious adverse events. American Journal of Tropical Medicine and Hygiene, 81 (6), p. 1056-1061. ISSN 0002-9637.
Titre du document
Loa loa microfilarial periodicity in ivermectin-treated patients : comparison between those developing and those free of serious adverse events
Kamgno J., Pion Sebastien D., Mackenzie C. D., Thylefors B., Boussinesq Michel
Source
American Journal of Tropical Medicine and Hygiene, 2009,
81 (6), p. 1056-1061 ISSN 0002-9637
The main risk factor of post-ivermectin serious adverse events (SAEs) is the presence of a high Loa loa microfilaremia. However, the majority of patients with such high loads do not develop SAEs, suggesting that co-factors may be involved. An infection with simian Loa parasites, whose microfilariae show a nocturnal periodicity, might be such a co-factor. The periodicity of Loa microfilariae was compared, using cosinor methodology, in 4 patients who had developed a post-ivermectin neurologic SAE, 4 patients who had experienced a non-neurologic SAE, and 14 control individuals. The periodicity was similar in all three groups, with a peak of microfilaremia occurring between 12:30 and 2:00 PM. The results of this study, which for the first time characterizes the periodicity of Loa microfilariae mathematically, suggest that post-ivermectin SAEs are not related to an infection with a Loa simian strain.
