@article{fdi:010048470,
  title = {{L}oa loa microfilarial periodicity in ivermectin-treated patients : comparison between those developing and those free of serious adverse events},
  author = {{K}amgno, {J}. and {P}ion, {S}ebastien {D}. and {M}ackenzie, {C}. {D}. and {T}hylefors, {B}. and {B}oussinesq, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he main risk factor of post-ivermectin serious adverse events ({SAE}s) is the presence of a high {L}oa loa microfilaremia. {H}owever, the majority of patients with such high loads do not develop {SAE}s, suggesting that co-factors may be involved. {A}n infection with simian {L}oa parasites, whose microfilariae show a nocturnal periodicity, might be such a co-factor. {T}he periodicity of {L}oa microfilariae was compared, using cosinor methodology, in 4 patients who had developed a post-ivermectin neurologic {SAE}, 4 patients who had experienced a non-neurologic {SAE}, and 14 control individuals. {T}he periodicity was similar in all three groups, with a peak of microfilaremia occurring between 12:30 and 2:00 {PM}. {T}he results of this study, which for the first time characterizes the periodicity of {L}oa microfilariae mathematically, suggest that post-ivermectin {SAE}s are not related to an infection with a {L}oa simian strain.},
  keywords = {},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {81},
  numero = {6},
  pages = {1056--1061},
  ISSN = {0002-9637},
  year = {2009},
  DOI = {10.4269/ajtmh.2009.09-0356},
  URL = {https://www.documentation.ird.fr/hor/fdi:010048470},
}