%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Kamgno, J.
%A Pion, Sebastien D.
%A Mackenzie, C. D.
%A Thylefors, B.
%A Boussinesq, Michel
%T Loa loa microfilarial periodicity in ivermectin-treated patients : comparison between those developing and those free of serious adverse events
%D 2009
%L fdi:010048470
%G ENG
%J American Journal of Tropical Medicine and Hygiene
%@ 0002-9637
%M ISI:000272709600021
%N 6
%P 1056-1061
%R 10.4269/ajtmh.2009.09-0356
%U https://www.documentation.ird.fr/hor/fdi:010048470
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-08/010048470.pdf
%V 81
%W Horizon (IRD)
%X The main risk factor of post-ivermectin serious adverse events (SAEs) is the presence of a high Loa loa microfilaremia. However, the majority of patients with such high loads do not develop SAEs, suggesting that co-factors may be involved. An infection with simian Loa parasites, whose microfilariae show a nocturnal periodicity, might be such a co-factor. The periodicity of Loa microfilariae was compared, using cosinor methodology, in 4 patients who had developed a post-ivermectin neurologic SAE, 4 patients who had experienced a non-neurologic SAE, and 14 control individuals. The periodicity was similar in all three groups, with a peak of microfilaremia occurring between 12:30 and 2:00 PM. The results of this study, which for the first time characterizes the periodicity of Loa microfilariae mathematically, suggest that post-ivermectin SAEs are not related to an infection with a Loa simian strain.
%$ 052