Kamgno J. auteur aut IRD Pion Sebastien D. auteur aut IRD Mackenzie C. D. auteur aut IRD Thylefors B. auteur aut IRD Boussinesq Michel auteur aut IRD text journalArticle eng text/pdf reformatted digital access The main risk factor of post-ivermectin serious adverse events (SAEs) is the presence of a high Loa loa microfilaremia. However, the majority of patients with such high loads do not develop SAEs, suggesting that co-factors may be involved. An infection with simian Loa parasites, whose microfilariae show a nocturnal periodicity, might be such a co-factor. The periodicity of Loa microfilariae was compared, using cosinor methodology, in 4 patients who had developed a post-ivermectin neurologic SAE, 4 patients who had experienced a non-neurologic SAE, and 14 control individuals. The periodicity was similar in all three groups, with a peak of microfilaremia occurring between 12:30 and 2:00 PM. The results of this study, which for the first time characterizes the periodicity of Loa microfilariae mathematically, suggest that post-ivermectin SAEs are not related to an infection with a Loa simian strain. specialized 052 81 6 1056-1061 2009 0002-9637 https://www.documentation.ird.fr/hor/fdi:010048470 10.4269/ajtmh.2009.09-0356 0002-9637 [F B010048470] https://www.documentation.ird.fr/hor/fdi:010048470 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-08/010048470.pdf IRD - Base Horizon / Pleins textes 2010-02-08 2020-09-17 fdi:010048470 fre