Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES American Journal of Tropical Medicine and Hygiene 1056-1061 2009 fdi:010048470 ENG American Journal of Tropical Medicine and Hygiene 0002-9637 ISI:000272709600021 6 10.4269/ajtmh.2009.09-0356 https://www.documentation.ird.fr/hor/fdi:010048470 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-08/010048470.pdf 81 Horizon (IRD) The main risk factor of post-ivermectin serious adverse events (SAEs) is the presence of a high Loa loa microfilaremia. However, the majority of patients with such high loads do not develop SAEs, suggesting that co-factors may be involved. An infection with simian Loa parasites, whose microfilariae show a nocturnal periodicity, might be such a co-factor. The periodicity of Loa microfilariae was compared, using cosinor methodology, in 4 patients who had developed a post-ivermectin neurologic SAE, 4 patients who had experienced a non-neurologic SAE, and 14 control individuals. The periodicity was similar in all three groups, with a peak of microfilaremia occurring between 12:30 and 2:00 PM. The results of this study, which for the first time characterizes the periodicity of Loa microfilariae mathematically, suggest that post-ivermectin SAEs are not related to an infection with a Loa simian strain. 052 UR145 Cameroun