Vidal Nicole, Frange P., Chaix M. L., Mulanga Claire, Lepira F., Bazepeo S. E., Goujard C., Meyer L., Rouzioux C., Delaporte Eric, Peeters Martine. (2008). Characterization of an old complex circulating recombinant form, CRF27_cpx, originating from the democratic republic of Congo (DRC) and circulating in France. Aids Research and Human Retroviruses, 24 (2), p. 315-321. ISSN 0889-2229.
Titre du document
Characterization of an old complex circulating recombinant form, CRF27_cpx, originating from the democratic republic of Congo (DRC) and circulating in France
Année de publication
2008
Auteurs
Vidal Nicole, Frange P., Chaix M. L., Mulanga Claire, Lepira F., Bazepeo S. E., Goujard C., Meyer L., Rouzioux C., Delaporte Eric, Peeters Martine
Source
Aids Research and Human Retroviruses, 2008,
24 (2), p. 315-321 ISSN 0889-2229
Full-length genomes were characterized for two samples, 02CD-LBR024 from the Democratic Republic of Congo (DRC) and 04FR-CD-KZS from France, that formed a separate subcluster with a previously characterized env subtype E isolate from DRC with a recombinant structure different from CRF01-AE. Since the three viruses are clearly epidemiologically unlinked and share the same complex recombinant structure, they represent a circulating recombinant form, designated as CRF27-cpx. The recombination pattern involves six different HIV-1 subtypes (A, E, G, H, J, and K) and a small unclassified fragment. The genetic distances are relatively high, indicating that CRF27-cpx evolved over a long time. Their prevalence is low (0.75%) and remained stable over time in the DRC. The existence of the 04FR. CD. KZS virus, in a patient who recently seroconverted in France, confirmed that these strains now circulate outside the DRC. Continuous monitoring of HIV-1 strains thus remains important to allow early identification of the introduction of new variants.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010040966]
Identifiant IRD
fdi:010040966
