%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Vidal, Nicole
%A Frange, P.
%A Chaix, M. L.
%A Mulanga, Claire
%A Lepira, F.
%A Bazepeo, S. E.
%A Goujard, C.
%A Meyer, L.
%A Rouzioux, C.
%A Delaporte, Eric
%A Peeters, Martine
%T Characterization of an old complex circulating recombinant form, CRF27_cpx, originating from the democratic republic of Congo (DRC) and circulating in France
%D 2008
%L fdi:010040966
%G ENG
%J Aids Research and Human Retroviruses
%@ 0889-2229
%M CC:0002535913-0023
%N 2
%P 315-321
%R 10.1089/aid.2007.0241
%U https://www.documentation.ird.fr/hor/fdi:010040966
%> https://www.documentation.ird.fr/intranet/publi/2008/03/010040966.pdf
%V 24
%W Horizon (IRD)
%X Full-length genomes were characterized for two samples, 02CD-LBR024 from the Democratic Republic of Congo (DRC) and 04FR-CD-KZS from France, that formed a separate subcluster with a previously characterized env subtype E isolate from DRC with a recombinant structure different from CRF01-AE. Since the three viruses are clearly epidemiologically unlinked and share the same complex recombinant structure, they represent a circulating recombinant form, designated as CRF27-cpx. The recombination pattern involves six different HIV-1 subtypes (A, E, G, H, J, and K) and a small unclassified fragment. The genetic distances are relatively high, indicating that CRF27-cpx evolved over a long time. Their prevalence is low (0.75%) and remained stable over time in the DRC. The existence of the 04FR. CD. KZS virus, in a patient who recently seroconverted in France, confirmed that these strains now circulate outside the DRC. Continuous monitoring of HIV-1 strains thus remains important to allow early identification of the introduction of new variants.
%$ 052