Vidal Nicole auteur aut IRD Frange P. auteur aut IRD Chaix M. L. auteur aut IRD Mulanga Claire auteur aut IRD Lepira F. auteur aut IRD Bazepeo S. E. auteur aut IRD Goujard C. auteur aut IRD Meyer L. auteur aut IRD Rouzioux C. auteur aut IRD Delaporte Eric auteur aut IRD Peeters Martine auteur aut IRD text journalArticle eng text/pdf born digital access Full-length genomes were characterized for two samples, 02CD-LBR024 from the Democratic Republic of Congo (DRC) and 04FR-CD-KZS from France, that formed a separate subcluster with a previously characterized env subtype E isolate from DRC with a recombinant structure different from CRF01-AE. Since the three viruses are clearly epidemiologically unlinked and share the same complex recombinant structure, they represent a circulating recombinant form, designated as CRF27-cpx. The recombination pattern involves six different HIV-1 subtypes (A, E, G, H, J, and K) and a small unclassified fragment. The genetic distances are relatively high, indicating that CRF27-cpx evolved over a long time. Their prevalence is low (0.75%) and remained stable over time in the DRC. The existence of the 04FR. CD. KZS virus, in a patient who recently seroconverted in France, confirmed that these strains now circulate outside the DRC. Continuous monitoring of HIV-1 strains thus remains important to allow early identification of the introduction of new variants. specialized 052 24 2 315-321 2008 0889-2229 https://www.documentation.ird.fr/hor/fdi:010040966 10.1089/aid.2007.0241 0889-2229 [F B010040966] https://www.documentation.ird.fr/hor/fdi:010040966 https://www.documentation.ird.fr/intranet/publi/2008/03/010040966.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2008-03-31 2017-08-23 fdi:010040966 fre