Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Aids Research and Human Retroviruses 315-321 2008 fdi:010040966 ENG Aids Research and Human Retroviruses 0889-2229 CC:0002535913-0023 2 10.1089/aid.2007.0241 https://www.documentation.ird.fr/hor/fdi:010040966 https://www.documentation.ird.fr/intranet/publi/2008/03/010040966.pdf 24 Horizon (IRD) Full-length genomes were characterized for two samples, 02CD-LBR024 from the Democratic Republic of Congo (DRC) and 04FR-CD-KZS from France, that formed a separate subcluster with a previously characterized env subtype E isolate from DRC with a recombinant structure different from CRF01-AE. Since the three viruses are clearly epidemiologically unlinked and share the same complex recombinant structure, they represent a circulating recombinant form, designated as CRF27-cpx. The recombination pattern involves six different HIV-1 subtypes (A, E, G, H, J, and K) and a small unclassified fragment. The genetic distances are relatively high, indicating that CRF27-cpx evolved over a long time. Their prevalence is low (0.75%) and remained stable over time in the DRC. The existence of the 04FR. CD. KZS virus, in a patient who recently seroconverted in France, confirmed that these strains now circulate outside the DRC. Continuous monitoring of HIV-1 strains thus remains important to allow early identification of the introduction of new variants. 052