Courgnaud V., Pourrut Xavier, Bibollet-Ruche F., Mpoudi Ngolé E., Bourgeois A., Delaporte Eric, Peeters Martine. (2001). Characterization of a novel simian immunodeficiency virus from guereza colobus monkeys (Colobus guereza) in Cameroon : a new lineage in the nonhuman primate lentivirus family. Journal of Virology, 75 (2), p. 857-866. ISSN 0022-538X.
Titre du document
Characterization of a novel simian immunodeficiency virus from guereza colobus monkeys (Colobus guereza) in Cameroon : a new lineage in the nonhuman primate lentivirus family
Année de publication
2001
Auteurs
Courgnaud V., Pourrut Xavier, Bibollet-Ruche F., Mpoudi Ngolé E., Bourgeois A., Delaporte Eric, Peeters Martine
Source
Journal of Virology, 2001,
75 (2), p. 857-866 ISSN 0022-538X
Exploration of the diversity among primate lentiviruses is necessary to elucidate the origins and evolution of immunodeficiency viruses. During a serological survey in Cameroon, we screened 25 wild-born guereza colobus monkeys (Colobus guereza) and identified 7 with HIV/SIV cross-reactive antibodies. In this study, we describe a novel lentivirus, named SIVcol, prevalent in guereza colobus monkeys. Genetic analysis revealed that SIVcol was very distinct from all other known SIV/HIV isolates, with average amino acid identities of 40% for Gag, 50% for Pol, 28% for Env, and around 25% for proteins encoded by five other genes. Phylogenetic analyses confirmed that SIVcol is genetically distinct from other previously characterized primate lentiviruses and clusters independently, forming a novel lineage, the sixth in the current classification. Cercopithecinae monkeys (Old World monkeys) are subdivided into two subfamilies, the Colobinae and the Cercopithecinae, and, so far, all Cercopithecidae monkeys from which lentiviruses have been isolated belong to the Cercopithecinae subfamily. Therefore, SIVcol from guereza colobus monkeys (C. guereza) is the first primate lentivirus identified in the Colobinae subfamily and the divergence of SIVcol may reflect divergence of the host lineage. (Résumé d'auteur)
Plan de classement
Maladies sexuellement transmissibles [052MALTRA03]
Descripteurs
SIDA ; VIRUS ; SINGE ; PHYLOGENIE ; ANALYSE GENETIQUE ; TECHNIQUE PCR ; ETUDE EXPERIMENTALE ; SIV ; BIOTAXONOMIE
Description Géographique
CAMEROUN
Localisation
Fonds IRD [F B010025995] ;
Montpellier (Centre IRD)
Identifiant IRD
fdi:010025995
