%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Courgnaud, V.
%A Pourrut, Xavier
%A Bibollet-Ruche, F.
%A Mpoudi Ngolé, E.
%A Bourgeois, A.
%A Delaporte, Eric
%A Peeters, Martine
%T Characterization of a novel simian immunodeficiency virus from guereza colobus monkeys (Colobus guereza) in Cameroon : a new lineage in the nonhuman primate lentivirus family
%D 2001
%L fdi:010025995
%G ENG
%J Journal of Virology
%@ 0022-538X
%K SIDA ; VIRUS ; SINGE ; PHYLOGENIE ; ANALYSE GENETIQUE ; TECHNIQUE PCR ; ETUDE EXPERIMENTALE
%K SIV ; BIOTAXONOMIE
%K CAMEROUN
%N 2
%P 857-866
%R 10.1128/JVI.75.2.857-866.2001
%U https://www.documentation.ird.fr/hor/fdi:010025995
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_59-60/010025995.pdf
%V 75
%W Horizon (IRD)
%X Exploration of the diversity among primate lentiviruses is necessary to elucidate the origins and evolution of immunodeficiency viruses. During a serological survey in Cameroon, we screened 25 wild-born guereza colobus monkeys (#Colobus guereza$) and identified 7 with HIV/SIV cross-reactive antibodies. In this study, we describe a novel lentivirus, named SIVcol, prevalent in guereza colobus monkeys. Genetic analysis revealed that SIVcol was very distinct from all other known SIV/HIV isolates, with average amino acid identities of 40% for Gag, 50% for Pol, 28% for Env, and around 25% for proteins encoded by five other genes. Phylogenetic analyses confirmed that SIVcol is genetically distinct from other previously characterized primate lentiviruses and clusters independently, forming a novel lineage, the sixth in the current classification. #Cercopithecinae$ monkeys (Old World monkeys) are subdivided into two subfamilies, the #Colobinae$ and the #Cercopithecinae$, and, so far, all #Cercopithecidae$ monkeys from which lentiviruses have been isolated belong to the #Cercopithecinae$ subfamily. Therefore, SIVcol from guereza colobus monkeys (#C. guereza$) is the first primate lentivirus identified in the #Colobinae$ subfamily and the divergence of SIVcol may reflect divergence of the host lineage. (Résumé d'auteur)
%$ 052MALTRA03