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Aaby Peter, Samb Badara, Simondon François, Knudsen K., Coll Seck A.M., Bennett J., Markowitz L., Wittle H. (1996). A comparison of vaccine efficacity and mortality during routine use of high-titre Edmonston-Zagreb and Schwarz standard measles vaccines in rural Senegal. Transactions of the Royal Society of Tropical Medicine and Hygiene, 90 (3), 326-330. ISSN 0035-9203

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Lien direct chez l'éditeur doi:10.1016/S0035-9203(96)90275-8

Titre
A comparison of vaccine efficacity and mortality during routine use of high-titre Edmonston-Zagreb and Schwarz standard measles vaccines in rural Senegal
Année de publication1996
Type de documentArticle
AuteursAaby Peter, Samb Badara, Simondon François, Knudsen K., Coll Seck A.M., Bennett J., Markowitz L., Wittle H.
SourceTransactions of the Royal Society of Tropical Medicine and Hygiene, 1996, 90 (3), p. 326-330. ISSN 0035-9203
RésuméVaccine efficacy and mortality in successive cohorts of children who routinely received either Edmonston-Zagreb high-titre (EZ-HT) or Schwarz standard (SW-STD) measles vaccines have been examined in a rural area of Senegal. The 2 vaccines were equally protective against measles infection (vaccination efficacy : EZ-HT 94 % ; SW-STD 93 %). Children who did not attend a scheduled session to receive measles vaccine had a higher mortality rate between 9 months and 2 years of age than did children receiveng either EZ-HT (mortality ratio [MR] = 1.81, 95 % confidence interval [CI] 1.06-3.08) or SW-STD measles vaccine (MR = 1.74, 95 % CI 0.95-3.21). Children of either sex vaccinated with EZ-HT had lower mortality than their equivalents who had not received any measles vaccine. There was no difference in overall mortality between recipients of EZ-HT and SW-STD (MR = 0.96, 95 % CI 0.70-1.30). Using a Cox regression analysis to adjust for sex, age and significant background factors (season and death of mother), mortality rates tended to be lower for male recipients of EZ-HT than for boys receiving SW-STD (MR = 0.73, 95 % CI 0.50-1.11) and higher for girls receiving EZ-HT than for girls receiving SW-STD (MR = 1.30, 95 % CI 0.81-2.09) (test of interaction between sex and vaccine, P = 0.067). The tendency to reduced survival benefit for girls following receipt of high-titre measles vaccines substantiated observations from randomized trials in Guinea-Bissau, Senegal and Haiti. Existing data provide little support for the notion that high-titre vaccine is deleterious but it may not have the same beneficial effects as standard-titre measles vaccine. (Résumé d'auteur)
Plan de classementDivers [050DIVSAN]
DescripteursROUGEOLE ; VACCINATION ; MORTALITE ; EFFICACITE ; MILIEU RURAL ; ETUDE COMPARATIVE ; VACCIN A HAUT TITRE ; EDMONSTON-ZAGREB ; SCHWARZ STANDARD
Descr. géo.SENEGAL ; NIAKHAR
LocalisationFonds IRD [F B010006215] ; Dakar ; Montpellier (Centre IRD)
Identifiant IRDfdi:010006215
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010006215

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