Aaby Peter auteur aut IRD Samb Badara auteur aut IRD Simondon François auteur aut IRD Knudsen K. auteur aut IRD Coll Seck A.M. auteur aut IRD Bennett J. auteur aut IRD Markowitz L. auteur aut IRD Wittle H. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Vaccine efficacy and mortality in successive cohorts of children who routinely received either Edmonston-Zagreb high-titre (EZ-HT) or Schwarz standard (SW-STD) measles vaccines have been examined in a rural area of Senegal. The 2 vaccines were equally protective against measles infection (vaccination efficacy : EZ-HT 94 % ; SW-STD 93 %). Children who did not attend a scheduled session to receive measles vaccine had a higher mortality rate between 9 months and 2 years of age than did children receiveng either EZ-HT (mortality ratio [MR] = 1.81, 95 % confidence interval [CI] 1.06-3.08) or SW-STD measles vaccine (MR = 1.74, 95 % CI 0.95-3.21). Children of either sex vaccinated with EZ-HT had lower mortality than their equivalents who had not received any measles vaccine. There was no difference in overall mortality between recipients of EZ-HT and SW-STD (MR = 0.96, 95 % CI 0.70-1.30). Using a Cox regression analysis to adjust for sex, age and significant background factors (season and death of mother), mortality rates tended to be lower for male recipients of EZ-HT than for boys receiving SW-STD (MR = 0.73, 95 % CI 0.50-1.11) and higher for girls receiving EZ-HT than for girls receiving SW-STD (MR = 1.30, 95 % CI 0.81-2.09) (test of interaction between sex and vaccine, P = 0.067). The tendency to reduced survival benefit for girls following receipt of high-titre measles vaccines substantiated observations from randomized trials in Guinea-Bissau, Senegal and Haiti. Existing data provide little support for the notion that high-titre vaccine is deleterious but it may not have the same beneficial effects as standard-titre measles vaccine. (Résumé d'auteur) specialized ROUGEOLE VACCINATION MORTALITE EFFICACITE MILIEU RURAL ETUDE COMPARATIVE VACCIN A HAUT TITRE EDMONSTON-ZAGREB SCHWARZ STANDARD SENEGAL 050DIVSAN 90 3 326-330 1996 0035-9203 https://www.documentation.ird.fr/hor/fdi:010006215 10.1016/S0035-9203(96)90275-8 0035-9203 [F B010006215] https://www.documentation.ird.fr/hor/fdi:010006215 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_45-46/010006215.pdf IRD - Base Horizon / Pleins textes 1996-07-15 2006-06-06 fdi:010006215 fre