%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Aaby, Peter
%A Samb, Badara
%A Simondon, François
%A Knudsen, K.
%A Coll Seck, A.M.
%A Bennett, J.
%A Markowitz, L.
%A Wittle, H.
%T A comparison of vaccine efficacity and mortality during routine use of high-titre Edmonston-Zagreb and Schwarz standard measles vaccines in rural Senegal
%D 1996
%L fdi:010006215
%G ENG
%J Transactions of the Royal Society of Tropical Medicine and Hygiene
%@ 0035-9203
%K ROUGEOLE ; VACCINATION ; MORTALITE ; EFFICACITE ; MILIEU RURAL ; ETUDE COMPARATIVE
%K VACCIN A HAUT TITRE ; EDMONSTON-ZAGREB ; SCHWARZ STANDARD
%K SENEGAL
%K NIAKHAR
%N 3
%P 326-330
%R 10.1016/S0035-9203(96)90275-8
%U https://www.documentation.ird.fr/hor/fdi:010006215
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_45-46/010006215.pdf
%V 90
%W Horizon (IRD)
%X Vaccine efficacy and mortality in successive cohorts of children who routinely received either Edmonston-Zagreb high-titre (EZ-HT) or Schwarz standard (SW-STD) measles vaccines have been examined in a rural area of Senegal. The 2 vaccines were equally protective against measles infection (vaccination efficacy : EZ-HT 94 % ; SW-STD 93 %). Children who did not attend a scheduled session to receive measles vaccine had a higher mortality rate between 9 months and 2 years of age than did children receiveng either EZ-HT (mortality ratio [MR] = 1.81, 95 % confidence interval [CI] 1.06-3.08) or SW-STD measles vaccine (MR = 1.74, 95 % CI 0.95-3.21). Children of either sex vaccinated with EZ-HT had lower mortality than their equivalents who had not received any measles vaccine. There was no difference in overall mortality between recipients of EZ-HT and SW-STD (MR = 0.96, 95 % CI 0.70-1.30). Using a Cox regression analysis to adjust for sex, age and significant background factors (season and death of mother), mortality rates tended to be lower for male recipients of EZ-HT than for boys receiving SW-STD (MR = 0.73, 95 % CI 0.50-1.11) and higher for girls receiving EZ-HT than for girls receiving SW-STD (MR = 1.30, 95 % CI 0.81-2.09) (test of interaction between sex and vaccine, P = 0.067). The tendency to reduced survival benefit for girls following receipt of high-titre measles vaccines substantiated observations from randomized trials in Guinea-Bissau, Senegal and Haiti. Existing data provide little support for the notion that high-titre vaccine is deleterious but it may not have the same beneficial effects as standard-titre measles vaccine. (Résumé d'auteur)
%$ 050DIVSAN