A comparison of vaccine efficacity and mortality during routine use of high-titre Edmonston-Zagreb and Schwarz standard measles vaccines in rural Senegal /Aaby, Peter /Samb, Badara /Simondon, François Knudsen, K. Coll Seck, A.M. Bennett, J. Markowitz, L. Wittle, H. ROUGEOLE VACCINATION MORTALITE EFFICACITE MILIEU RURAL ETUDE COMPARATIVE VACCIN A HAUT TITRE EDMONSTON-ZAGREB SCHWARZ STANDARD Vaccine efficacy and mortality in successive cohorts of children who routinely received either Edmonston-Zagreb high-titre (EZ-HT) or Schwarz standard (SW-STD) measles vaccines have been examined in a rural area of Senegal. The 2 vaccines were equally protective against measles infection (vaccination efficacy : EZ-HT 94 % ; SW-STD 93 %). Children who did not attend a scheduled session to receive measles vaccine had a higher mortality rate between 9 months and 2 years of age than did children receiveng either EZ-HT (mortality ratio [MR] = 1.81, 95 % confidence interval [CI] 1.06-3.08) or SW-STD measles vaccine (MR = 1.74, 95 % CI 0.95-3.21). Children of either sex vaccinated with EZ-HT had lower mortality than their equivalents who had not received any measles vaccine. There was no difference in overall mortality between recipients of EZ-HT and SW-STD (MR = 0.96, 95 % CI 0.70-1.30). Using a Cox regression analysis to adjust for sex, age and significant background factors (season and death of mother), mortality rates tended to be lower for male recipients of EZ-HT than for boys receiving SW-STD (MR = 0.73, 95 % CI 0.50-1.11) and higher for girls receiving EZ-HT than for girls receiving SW-STD (MR = 1.30, 95 % CI 0.81-2.09) (test of interaction between sex and vaccine, P = 0.067). The tendency to reduced survival benefit for girls following receipt of high-titre measles vaccines substantiated observations from randomized trials in Guinea-Bissau, Senegal and Haiti. Existing data provide little support for the notion that high-titre vaccine is deleterious but it may not have the same beneficial effects as standard-titre measles vaccine. (Résumé d'auteur) 1996 text https://www.documentation.ird.fr/hor/fdi:010006215 fdi:010006215 Aaby Peter, Samb Badara, Simondon François, Knudsen K., Coll Seck A.M., Bennett J., Markowitz L., Wittle H.. A comparison of vaccine efficacity and mortality during routine use of high-titre Edmonston-Zagreb and Schwarz standard measles vaccines in rural Senegal. 1996, 90 (3), 326-330 EN SENEGAL