@article{fdi:010006215,
  title = {{A} comparison of vaccine efficacity and mortality during routine use of high-titre {E}dmonston-{Z}agreb and {S}chwarz standard measles vaccines in rural {S}enegal},
  author = {{A}aby, {P}eter and {S}amb, {B}adara and {S}imondon, {F}ran{\c{c}}ois and {K}nudsen, {K}. and {C}oll {S}eck, {A}.{M}. and {B}ennett, {J}. and {M}arkowitz, {L}. and {W}ittle, {H}.},
  editor = {},
  language = {{ENG}},
  abstract = {{V}accine efficacy and mortality in successive cohorts of children who routinely received either {E}dmonston-{Z}agreb high-titre ({EZ}-{HT}) or {S}chwarz standard ({SW}-{STD}) measles vaccines have been examined in a rural area of {S}enegal. {T}he 2 vaccines were equally protective against measles infection (vaccination efficacy : {EZ}-{HT} 94 % ; {SW}-{STD} 93 %). {C}hildren who did not attend a scheduled session to receive measles vaccine had a higher mortality rate between 9 months and 2 years of age than did children receiveng either {EZ}-{HT} (mortality ratio [{MR}] = 1.81, 95 % confidence interval [{CI}] 1.06-3.08) or {SW}-{STD} measles vaccine ({MR} = 1.74, 95 % {CI} 0.95-3.21). {C}hildren of either sex vaccinated with {EZ}-{HT} had lower mortality than their equivalents who had not received any measles vaccine. {T}here was no difference in overall mortality between recipients of {EZ}-{HT} and {SW}-{STD} ({MR} = 0.96, 95 % {CI} 0.70-1.30). {U}sing a {C}ox regression analysis to adjust for sex, age and significant background factors (season and death of mother), mortality rates tended to be lower for male recipients of {EZ}-{HT} than for boys receiving {SW}-{STD} ({MR} = 0.73, 95 % {CI} 0.50-1.11) and higher for girls receiving {EZ}-{HT} than for girls receiving {SW}-{STD} ({MR} = 1.30, 95 % {CI} 0.81-2.09) (test of interaction between sex and vaccine, {P} = 0.067). {T}he tendency to reduced survival benefit for girls following receipt of high-titre measles vaccines substantiated observations from randomized trials in {G}uinea-{B}issau, {S}enegal and {H}aiti. {E}xisting data provide little support for the notion that high-titre vaccine is deleterious but it may not have the same beneficial effects as standard-titre measles vaccine. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{ROUGEOLE} ; {VACCINATION} ; {MORTALITE} ; {EFFICACITE} ; {MILIEU} {RURAL} ; {ETUDE} {COMPARATIVE} ; {VACCIN} {A} {HAUT} {TITRE} ; {EDMONSTON}-{ZAGREB} ; {SCHWARZ} {STANDARD} ; {SENEGAL} ; {NIAKHAR}},
  booktitle = {},
  journal = {{T}ransactions of the {R}oyal {S}ociety of {T}ropical {M}edicine and {H}ygiene},
  volume = {90},
  numero = {3},
  pages = {326--330},
  ISSN = {0035-9203},
  year = {1996},
  DOI = {10.1016/{S}0035-9203(96)90275-8},
  URL = {https://www.documentation.ird.fr/hor/fdi:010006215},
}