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Sarr H., Niang A. A., Diop A., Mediannikov Oleg, Zerrouki H., Diene S. M., Lo S. Y. B., Dia M. L., Sow A. I., Fenollar F., Rolain J. M., Hadjadj L., Calia C., Young L. S. (2023). The emergence of carbapenem- and colistin-resistant enterobacteria in Senegal. Pathogens, 12 (8), 974 [11 p.].

Titre du document
The emergence of carbapenem- and colistin-resistant enterobacteria in Senegal
Année de publication
2023
Type de document
Article référencé dans le Web of Science WOS:001055278900001
Auteurs
Sarr H., Niang A. A., Diop A., Mediannikov Oleg, Zerrouki H., Diene S. M., Lo S. Y. B., Dia M. L., Sow A. I., Fenollar F., Rolain J. M., Hadjadj L., Calia C., Young L. S.
Source
Pathogens, 2023, 12 (8), 974 [11 p.]
Antibiotic resistance is a public health problem. The emergence of carbapenemase-producing Enterobacterales (CPE) infections is a concern, particularly in Senegal. (1) Methods: Between January 2019 and July 2022, 240 isolates of enterobacteria resistant to third-generation cephalosporins and imipenem from biological samples from Fann Hospital (Dakar) and Hopital Paix (Ziguinchor) were selected. The isolates were identified by MALDI-TOF mass spectrometry, and susceptibility tests were performed by the disk diffusion method. Antibiotic-resistance genes for class A beta-lactamases, carbapenemases, and plasmid resistance to colistin resistance (mcr-1-8) were screened by RT-PCR. (2) Results: The 240 enterobacteria were composed of: Escherichia coli (60.83%), Klebsiella pneumoniae (21.67%), Enterobacter cloacae (13.75%), Citrobacter freundii (2.08%), Serratia marcescens (0.83%), Klebsiella aerogenes (0.42%), and Proteus mirabilis (0.42%). Class A beta-lactamase genes were found in 229 isolates (70.41% bla(TEM), 37.5% bla(SHV), 83.75% bla(CTX-A), and 0.42% bla(CTX-B)). The carbapenemase genes bla(OXA-48) and bla(NDM) were found in 25 isolates, including 14 isolates with bla(OXA-48), 13 isolates with bla(NDM), and 2 isolates with both genes simultaneously. The mcr-8 gene was found in one isolate of E. cloacae. (3) Conclusions: The epidemiology of antibiotic-resistance genes in enterobacteria in Senegal shows the emergence of CPEs. This phenomenon is worrying, and rigorous surveillance is necessary to avoid further spread.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020] ; Santé : généralités [050] ; Biotechnologies [084]
Description Géographique
SENEGAL
Localisation
Fonds IRD [F B010090174]
Identifiant IRD
fdi:010090174
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