Sarr H. auteur aut IRD Niang A. A. auteur aut IRD Diop A. auteur aut IRD Mediannikov Oleg auteur aut IRD Zerrouki H. auteur aut IRD Diene S. M. auteur aut IRD Lo S. Y. B. auteur aut IRD Dia M. L. auteur aut IRD Sow A. I. auteur aut IRD Fenollar F. auteur aut IRD Rolain J. M. auteur aut IRD Hadjadj L. auteur aut IRD Calia C. auteur aut IRD Young L. S. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Antibiotic resistance is a public health problem. The emergence of carbapenemase-producing Enterobacterales (CPE) infections is a concern, particularly in Senegal. (1) Methods: Between January 2019 and July 2022, 240 isolates of enterobacteria resistant to third-generation cephalosporins and imipenem from biological samples from Fann Hospital (Dakar) and Hopital Paix (Ziguinchor) were selected. The isolates were identified by MALDI-TOF mass spectrometry, and susceptibility tests were performed by the disk diffusion method. Antibiotic-resistance genes for class A beta-lactamases, carbapenemases, and plasmid resistance to colistin resistance (mcr-1-8) were screened by RT-PCR. (2) Results: The 240 enterobacteria were composed of: Escherichia coli (60.83%), Klebsiella pneumoniae (21.67%), Enterobacter cloacae (13.75%), Citrobacter freundii (2.08%), Serratia marcescens (0.83%), Klebsiella aerogenes (0.42%), and Proteus mirabilis (0.42%). Class A beta-lactamase genes were found in 229 isolates (70.41% bla(TEM), 37.5% bla(SHV), 83.75% bla(CTX-A), and 0.42% bla(CTX-B)). The carbapenemase genes bla(OXA-48) and bla(NDM) were found in 25 isolates, including 14 isolates with bla(OXA-48), 13 isolates with bla(NDM), and 2 isolates with both genes simultaneously. The mcr-8 gene was found in one isolate of E. cloacae. (3) Conclusions: The epidemiology of antibiotic-resistance genes in enterobacteria in Senegal shows the emergence of CPEs. This phenomenon is worrying, and rigorous surveillance is necessary to avoid further spread. specialized enterobacteria carbapenemase colistin SENEGAL 084 050 020 12 8 974 [11 ] 2023 https://www.documentation.ird.fr/hor/fdi:010090174 10.3390/pathogens12080974 [F B010090174] https://www.documentation.ird.fr/hor/fdi:010090174 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2023-10/010090174.pdf IRD - Base Horizon / Pleins textes 2023-10-06 2025-02-24 fdi:010090174 fre