@article{fdi:010090174,
  title = {{T}he emergence of carbapenem- and colistin-resistant enterobacteria in {S}enegal},
  author = {{S}arr, {H}. and {N}iang, {A}. {A}. and {D}iop, {A}. and {M}ediannikov, {O}leg and {Z}errouki, {H}. and {D}iene, {S}. {M}. and {L}o, {S}. {Y}. {B}. and {D}ia, {M}. {L}. and {S}ow, {A}. {I}. and {F}enollar, {F}. and {R}olain, {J}. {M}. and {H}adjadj, {L}. and {C}alia, {C}. and {Y}oung, {L}. {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}ntibiotic resistance is a public health problem. {T}he emergence of carbapenemase-producing {E}nterobacterales ({CPE}) infections is a concern, particularly in {S}enegal. (1) {M}ethods: {B}etween {J}anuary 2019 and {J}uly 2022, 240 isolates of enterobacteria resistant to third-generation cephalosporins and imipenem from biological samples from {F}ann {H}ospital ({D}akar) and {H}opital {P}aix ({Z}iguinchor) were selected. {T}he isolates were identified by {MALDI}-{TOF} mass spectrometry, and susceptibility tests were performed by the disk diffusion method. {A}ntibiotic-resistance genes for class {A} beta-lactamases, carbapenemases, and plasmid resistance to colistin resistance (mcr-1-8) were screened by {RT}-{PCR}. (2) {R}esults: {T}he 240 enterobacteria were composed of: {E}scherichia coli (60.83%), {K}lebsiella pneumoniae (21.67%), {E}nterobacter cloacae (13.75%), {C}itrobacter freundii (2.08%), {S}erratia marcescens (0.83%), {K}lebsiella aerogenes (0.42%), and {P}roteus mirabilis (0.42%). {C}lass {A} beta-lactamase genes were found in 229 isolates (70.41% bla({TEM}), 37.5% bla({SHV}), 83.75% bla({CTX}-{A}), and 0.42% bla({CTX}-{B})). {T}he carbapenemase genes bla({OXA}-48) and bla({NDM}) were found in 25 isolates, including 14 isolates with bla({OXA}-48), 13 isolates with bla({NDM}), and 2 isolates with both genes simultaneously. {T}he mcr-8 gene was found in one isolate of {E}. cloacae. (3) {C}onclusions: {T}he epidemiology of antibiotic-resistance genes in enterobacteria in {S}enegal shows the emergence of {CPE}s. {T}his phenomenon is worrying, and rigorous surveillance is necessary to avoid further spread.},
  keywords = {enterobacteria ; carbapenemase ; colistin ; {SENEGAL}},
  booktitle = {},
  journal = {{P}athogens},
  volume = {12},
  numero = {8},
  pages = {974 [11 ]},
  year = {2023},
  DOI = {10.3390/pathogens12080974},
  URL = {https://www.documentation.ird.fr/hor/fdi:010090174},
}