Duffy antigen is expressed during erythropoiesis in Duffy-negative individuals

2023

Article référencé dans le Web of Science WOS:001139056200001

Dechavanne Célia, Dechavanne S., Bosch J., Metral S., Redinger K. R., Watson Q. D., Ratsimbasoa A. C., Roeper B., Krishnan S., Fong R., Bennett S., Carias L., Chen E. D., Salinas N. D., Ghosh A., Tolia N. H., Woost P. G., Jacobberger J. W., Colin Y., Gamain B., King C. L., Zimmerman P. A.

Cell Host and Microbe, 2023, 31 (12), p. [22 p.] ISSN 1931-3128

The erythrocyte silent Duffy blood group phenotype in Africans is thought to confer resistance to Plasmodium vivax blood-stage infection. However, recent studies report P. vivax infections across Africa in Fy-negative individuals. This suggests that the globin transcription factor 1 (GATA-1) SNP underlying Fy negativity does not entirely abolish Fy expression or that P. vivax has developed a Fy-independent red blood cell (RBC) invasion pathway. We show that RBCs and erythroid progenitors from in vitro differentiated CD34 cells and from bone marrow aspirates from Fy-negative samples express a functional Fy on their surface. This suggests that the GATA-1 SNP does not entirely abolish Fy expression. Given these results, we developed an in vitro culture system for P. vivax and show P. vivax can invade erythrocytes from Duffy-negative individuals. This study provides evidence that Fy is expressed in Fy-negative individuals and explains their susceptibility to P. vivax with major implications and challenges for P. vivax malaria eradication.

Sciences fondamentales / Techniques d'analyse et de recherche [020] ; Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]

Fonds IRD [F B010088919]

fdi:010088919