@article{fdi:010088919,
  title = {{D}uffy antigen is expressed during erythropoiesis in {D}uffy-negative individuals},
  author = {{D}echavanne, {C}{\'e}lia and {D}echavanne, {S}. and {B}osch, {J}. and {M}etral, {S}. and {R}edinger, {K}. {R}. and {W}atson, {Q}. {D}. and {R}atsimbasoa, {A}. {C}. and {R}oeper, {B}. and {K}rishnan, {S}. and {F}ong, {R}. and {B}ennett, {S}. and {C}arias, {L}. and {C}hen, {E}. {D}. and {S}alinas, {N}. {D}. and {G}hosh, {A}. and {T}olia, {N}. {H}. and {W}oost, {P}. {G}. and {J}acobberger, {J}. {W}. and {C}olin, {Y}. and {G}amain, {B}. and {K}ing, {C}. {L}. and {Z}immerman, {P}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he erythrocyte silent {D}uffy blood group phenotype in {A}fricans is thought to confer resistance to {P}lasmodium vivax blood-stage infection. {H}owever, recent studies report {P}. vivax infections across {A}frica in {F}y-negative individuals. {T}his suggests that the globin transcription factor 1 ({GATA}-1) {SNP} underlying {F}y negativity does not entirely abolish {F}y expression or that {P}. vivax has developed a {F}y-independent red blood cell ({RBC}) invasion pathway. {W}e show that {RBC}s and erythroid progenitors from in vitro differentiated {CD}34 cells and from bone marrow aspirates from {F}y-negative samples express a functional {F}y on their surface. {T}his suggests that the {GATA}-1 {SNP} does not entirely abolish {F}y expression. {G}iven these results, we developed an in vitro culture system for {P}. vivax and show {P}. vivax can invade erythrocytes from {D}uffy-negative individuals. {T}his study provides evidence that {F}y is expressed in {F}y-negative individuals and explains their susceptibility to {P}. vivax with major implications and challenges for {P}. vivax malaria eradication.},
  keywords = {{AFRIQUE}},
  booktitle = {},
  journal = {{C}ell {H}ost and {M}icrobe},
  volume = {31},
  numero = {12},
  pages = {[22 p.]},
  ISSN = {1931-3128},
  year = {2023},
  DOI = {10.1016/j.chom.2023.10.019},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088919},
}