%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Dechavanne, Célia
%A Dechavanne, S.
%A Bosch, J.
%A Metral, S.
%A Redinger, K. R.
%A Watson, Q. D.
%A Ratsimbasoa, A. C.
%A Roeper, B.
%A Krishnan, S.
%A Fong, R.
%A Bennett, S.
%A Carias, L.
%A Chen, E. D.
%A Salinas, N. D.
%A Ghosh, A.
%A Tolia, N. H.
%A Woost, P. G.
%A Jacobberger, J. W.
%A Colin, Y.
%A Gamain, B.
%A King, C. L.
%A Zimmerman, P. A.
%T Duffy antigen is expressed during erythropoiesis in Duffy-negative individuals
%D 2023
%L fdi:010088919
%G ENG
%J Cell Host and Microbe
%@ 1931-3128
%K AFRIQUE
%M ISI:001139056200001
%N 12
%P [22 ]
%R 10.1016/j.chom.2023.10.019
%U https://www.documentation.ird.fr/hor/fdi:010088919
%> https://www.documentation.ird.fr/intranet/publi/2024-02/010088919.pdf
%V 31
%W Horizon (IRD)
%X The erythrocyte silent Duffy blood group phenotype in Africans is thought to confer resistance to Plasmodium vivax blood-stage infection. However, recent studies report P. vivax infections across Africa in Fy-negative individuals. This suggests that the globin transcription factor 1 (GATA-1) SNP underlying Fy negativity does not entirely abolish Fy expression or that P. vivax has developed a Fy-independent red blood cell (RBC) invasion pathway. We show that RBCs and erythroid progenitors from in vitro differentiated CD34 cells and from bone marrow aspirates from Fy-negative samples express a functional Fy on their surface. This suggests that the GATA-1 SNP does not entirely abolish Fy expression. Given these results, we developed an in vitro culture system for P. vivax and show P. vivax can invade erythrocytes from Duffy-negative individuals. This study provides evidence that Fy is expressed in Fy-negative individuals and explains their susceptibility to P. vivax with major implications and challenges for P. vivax malaria eradication.
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