Publications des scientifiques de l'IRD

Assogba B. S., Djogbenou L. S., Milesi P., Berthomieu A., Perez J., Ayala Diego, Chandre Fabrice, Makoutode M., Labbe P., Weill M. (2015). An ace-1 gene duplication resorbs the fitness cost associated with resistance in Anopheles gambiae, the main malaria mosquito. Scientific Reports - Nature, 5, p. art. 14529 [12 p.]. ISSN 2045-2322.

Titre du document
An ace-1 gene duplication resorbs the fitness cost associated with resistance in Anopheles gambiae, the main malaria mosquito
Année de publication
2015
Type de document
Article référencé dans le Web of Science WOS:000362179300001
Auteurs
Assogba B. S., Djogbenou L. S., Milesi P., Berthomieu A., Perez J., Ayala Diego, Chandre Fabrice, Makoutode M., Labbe P., Weill M.
Source
Scientific Reports - Nature, 2015, 5, p. art. 14529 [12 p.] ISSN 2045-2322
Widespread resistance to pyrethroids threatens malaria control in Africa. Consequently, several countries switched to carbamates and organophophates insecticides for indoor residual spraying. However, a mutation in the ace-1 gene conferring resistance to these compounds (ace-1(R) allele), is already present. Furthermore, a duplicated allele (ace-1(D)) recently appeared; characterizing its selective advantage is mandatory to evaluate the threat. Our data revealed that a unique duplication event, pairing a susceptible and a resistant copy of the ace-1 gene spread through West Africa. Further investigations revealed that, while ace-1(D) confers less resistance than ace-1(R), the high fitness cost associated with ace-1(R) is almost completely suppressed by the duplication for all traits studied. ace-1 duplication thus represents a permanent heterozygote phenotype, selected, and thus spreading, due to the mosaic nature of mosquito control. It provides malaria mosquito with a new evolutionary path that could hamper resistance management.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
AFRIQUE SUBSAHARIENNE
Localisation
Fonds IRD [F B010065360]
Identifiant IRD
fdi:010065360
Contact