%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Assogba, B. S.
%A Djogbenou, L. S.
%A Milesi, P.
%A Berthomieu, A.
%A Perez, J.
%A Ayala, Diego
%A Chandre, Fabrice
%A Makoutode, M.
%A Labbe, P.
%A Weill, M.
%T An ace-1 gene duplication resorbs the fitness cost associated with resistance in Anopheles gambiae, the main malaria mosquito
%D 2015
%L fdi:010065360
%G ENG
%J Scientific Reports - Nature
%@ 2045-2322
%K AFRIQUE SUBSAHARIENNE
%M ISI:000362179300001
%P art. 14529 [12 ]
%R 10.1038/srep14529
%U https://www.documentation.ird.fr/hor/fdi:010065360
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-10/010065360.pdf
%V 5
%W Horizon (IRD)
%X Widespread resistance to pyrethroids threatens malaria control in Africa. Consequently, several countries switched to carbamates and organophophates insecticides for indoor residual spraying. However, a mutation in the ace-1 gene conferring resistance to these compounds (ace-1(R) allele), is already present. Furthermore, a duplicated allele (ace-1(D)) recently appeared; characterizing its selective advantage is mandatory to evaluate the threat. Our data revealed that a unique duplication event, pairing a susceptible and a resistant copy of the ace-1 gene spread through West Africa. Further investigations revealed that, while ace-1(D) confers less resistance than ace-1(R), the high fitness cost associated with ace-1(R) is almost completely suppressed by the duplication for all traits studied. ace-1 duplication thus represents a permanent heterozygote phenotype, selected, and thus spreading, due to the mosaic nature of mosquito control. It provides malaria mosquito with a new evolutionary path that could hamper resistance management.
%$ 052