@article{fdi:010065360,
  title = {{A}n ace-1 gene duplication resorbs the fitness cost associated with resistance in {A}nopheles gambiae, the main malaria mosquito},
  author = {{A}ssogba, {B}. {S}. and {D}jogbenou, {L}. {S}. and {M}ilesi, {P}. and {B}erthomieu, {A}. and {P}erez, {J}. and {A}yala, {D}iego and {C}handre, {F}abrice and {M}akoutode, {M}. and {L}abbe, {P}. and {W}eill, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}idespread resistance to pyrethroids threatens malaria control in {A}frica. {C}onsequently, several countries switched to carbamates and organophophates insecticides for indoor residual spraying. {H}owever, a mutation in the ace-1 gene conferring resistance to these compounds (ace-1({R}) allele), is already present. {F}urthermore, a duplicated allele (ace-1({D})) recently appeared; characterizing its selective advantage is mandatory to evaluate the threat. {O}ur data revealed that a unique duplication event, pairing a susceptible and a resistant copy of the ace-1 gene spread through {W}est {A}frica. {F}urther investigations revealed that, while ace-1({D}) confers less resistance than ace-1({R}), the high fitness cost associated with ace-1({R}) is almost completely suppressed by the duplication for all traits studied. ace-1 duplication thus represents a permanent heterozygote phenotype, selected, and thus spreading, due to the mosaic nature of mosquito control. {I}t provides malaria mosquito with a new evolutionary path that could hamper resistance management.},
  keywords = {{AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {5},
  numero = {},
  pages = {art. 14529 [12 p.]},
  ISSN = {2045-2322},
  year = {2015},
  DOI = {10.1038/srep14529},
  URL = {https://www.documentation.ird.fr/hor/fdi:010065360},
}