Pornprasert S., Mary J. Y., Faye A., Leechanachai P., Limtrakul A., Rugpao S., Sirivatanapa P., Gomuthbutra V., Matanasaravoot W., Le Coeur Sophie, Lallemant Marc, Barre-Sinoussi F., Menu E., Ngo-Giang-Huong Nicole. (2009). Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 Infected women receiving longer Zidovudine prophylaxis associated with Nevirapine. Current Hiv Research, 7 (2), p. 211-217. ISSN 1570-162X.
Titre du document
Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 Infected women receiving longer Zidovudine prophylaxis associated with Nevirapine
Année de publication
2009
Auteurs
Pornprasert S., Mary J. Y., Faye A., Leechanachai P., Limtrakul A., Rugpao S., Sirivatanapa P., Gomuthbutra V., Matanasaravoot W., Le Coeur Sophie, Lallemant Marc, Barre-Sinoussi F., Menu E., Ngo-Giang-Huong Nicole
Source
Current Hiv Research, 2009,
7 (2), p. 211-217 ISSN 1570-162X
Placental cytokine balance may be critical for the control of mother-to-child transmission (MTCT) of HIV. We assessed whether the type and duration of antiretrovirals used for prevention of HIV-1-MTCT modified the inflammatory cytokine profile. We investigated the levels of cytokine expression in the placentas of 61 HIV-1-infected women who received zidovudine (ZDV) plus single dose nevirapine (SD-NVP) or ZDV only for prevention of MTCT. Placentas of 38 HIV-1-uninfected women were included as controls. All placentas were obtained after vaginal delivery. Levels of mRNA and cytokine expression were quantified using real-time PCR and ELISA, respectively, in placental explants and 24-hour culture supernatants and analyzed in relation to the women's characteristics and the type and duration of antiretroviral prophylaxis. HIV-1-infected and uninfected women did not show any differences in the expression of placental cytokine secretion except for a trend toward lower TNF-alpha mRNA levels in HIV-1-infected women. Within the HIV-1-infected group, women who were exposed to a long duration of ZDV (> 72 days) or received SD-NVP less than 5h prior to delivery, more frequently expressed detectable levels of IL-10 in their placentas (32% versus 7% (p = 0.01) and 32% versus 5% (p = 0.02), respectively). No infant was found to be HIV-1-infected. Our results showed a normalization of the placental cytokine balance in HIV-1-infected women receiving antiretroviral prophylaxis. Furthermore, the type and duration of antiretroviral prophylaxis have an impact on the placental anti-inflammatory IL-10 expression level, which may contribute to controlling HIV replication at the placental level, thus reducing MTCT of HIV-1.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010052479]
Identifiant IRD
fdi:010052479
