@article{fdi:010052479,
  title = {{H}igher placental anti-inflammatory {IL}-10 cytokine expression in {HIV}-1 {I}nfected women receiving longer {Z}idovudine prophylaxis associated with {N}evirapine},
  author = {{P}ornprasert, {S}. and {M}ary, {J}. {Y}. and {F}aye, {A}. and {L}eechanachai, {P}. and {L}imtrakul, {A}. and {R}ugpao, {S}. and {S}irivatanapa, {P}. and {G}omuthbutra, {V}. and {M}atanasaravoot, {W}. and {L}e {C}oeur, {S}ophie and {L}allemant, {M}arc and {B}arre-{S}inoussi, {F}. and {M}enu, {E}. and {N}go-{G}iang-{H}uong, {N}icole},
  editor = {},
  language = {{ENG}},
  abstract = {{P}lacental cytokine balance may be critical for the control of mother-to-child transmission ({MTCT}) of {HIV}. {W}e assessed whether the type and duration of antiretrovirals used for prevention of {HIV}-1-{MTCT} modified the inflammatory cytokine profile. {W}e investigated the levels of cytokine expression in the placentas of 61 {HIV}-1-infected women who received zidovudine ({ZDV}) plus single dose nevirapine ({SD}-{NVP}) or {ZDV} only for prevention of {MTCT}. {P}lacentas of 38 {HIV}-1-uninfected women were included as controls. {A}ll placentas were obtained after vaginal delivery. {L}evels of m{RNA} and cytokine expression were quantified using real-time {PCR} and {ELISA}, respectively, in placental explants and 24-hour culture supernatants and analyzed in relation to the women's characteristics and the type and duration of antiretroviral prophylaxis. {HIV}-1-infected and uninfected women did not show any differences in the expression of placental cytokine secretion except for a trend toward lower {TNF}-alpha m{RNA} levels in {HIV}-1-infected women. {W}ithin the {HIV}-1-infected group, women who were exposed to a long duration of {ZDV} (> 72 days) or received {SD}-{NVP} less than 5h prior to delivery, more frequently expressed detectable levels of {IL}-10 in their placentas (32% versus 7% (p = 0.01) and 32% versus 5% (p = 0.02), respectively). {N}o infant was found to be {HIV}-1-infected. {O}ur results showed a normalization of the placental cytokine balance in {HIV}-1-infected women receiving antiretroviral prophylaxis. {F}urthermore, the type and duration of antiretroviral prophylaxis have an impact on the placental anti-inflammatory {IL}-10 expression level, which may contribute to controlling {HIV} replication at the placental level, thus reducing {MTCT} of {HIV}-1.},
  keywords = {{HIV}-1 ; placenta ; antiretroviral prophylaxis ; zidovudine and nevirapine ; {IL}-10 cytokine ; mother-to-child transmission},
  booktitle = {},
  journal = {{C}urrent {H}iv {R}esearch},
  volume = {7},
  numero = {2},
  pages = {211--217},
  ISSN = {1570-162{X}},
  year = {2009},
  URL = {https://www.documentation.ird.fr/hor/fdi:010052479},
}