Publications des scientifiques de l'IRD

Campagne G., Garba A., Fabre P., Schuchat A., Ryall R., Boulanger D., Bybel M., Carlone G., Briantais P., Ivanoff B., Xerri B., Chippaux Jean-Philippe. (2000). Safety and immunogenicity of three doses of a Neisseria meningitidis A + C diphtheria conjugate vaccine in infants from Niger. Pediatric Infectious Disease Journal, 19, p. 144-150. ISSN 0891-3668.

Titre du document
Safety and immunogenicity of three doses of a Neisseria meningitidis A + C diphtheria conjugate vaccine in infants from Niger
Année de publication
2000
Type de document
Article
Auteurs
Campagne G., Garba A., Fabre P., Schuchat A., Ryall R., Boulanger D., Bybel M., Carlone G., Briantais P., Ivanoff B., Xerri B., Chippaux Jean-Philippe
Source
Pediatric Infectious Disease Journal, 2000, 19, p. 144-150 ISSN 0891-3668
Background : High rates of endemic disease and recurrent epidemics of serogroup A and C meningococcal meningitis continue to occur in sub-Saharan Africa. A meningococcal A+ + C polysaccharide diptheria-toxoid-conjugated vaccine may address this issue. Methods : In Niger three doses of a bivalent meningococcal A + C diphtheria-toxoid-conjugated vaccine (MenD), containing 1, 4 or 16 micrometer grams of each polysaccharide per dose, administered at 6, 10 and 14 weeks of age, were compared with Haemophilus influenzae type b-tetanus toxoid-conjugated (PRP-T) vaccine given with the same schedule or with a meningococcal A + C polysacharide vaccine (MenPS) given at 10 and 14 weeks of age. One blood sample was taken at the time of enrollment (6 weeks of age) and another was taken 4 weeks after the primary series. Results : all doses of MenD were well-tolerated. After the primary series a higher proportion of infants had detectable serum bactericidal activity against serogroup A for each dose of MenD (from 94% to 100%) than for MenPS (31%) or H. influenzae type b-tetanus toxoid-conjuugated vaccine (18.9%) ; P is less than or equal to 0.05. Significant differences were also observed for serogroup C MenD 4 micrometer grams or MenD 16 micrometer grams (100%) vs. MenPS (69.7%) or Haemophilus influenzae type b-tetanus toxoid-conjugated vaccine (24.3%) ; P is less than or equal to 0.05. When MenPS vaccine was given to 11-month children, the immune response measured by both enzyme-linked immunosorbent assay and serum bactericidal assay was greater in those previously immunized with MenD than in those immunized with MenPS vaccine. Conclusion : MenD was safe among infants in Niger, and immunization led to significantly greater functional antibody activity than with MenPS. The 4-micrometer gram dose of MedD for both the A and C serogroups has been selected for further studies. (Résumé d'auteur)
Plan de classement
Divers [052MALTRA05]
Descripteurs
EPIDEMIE ; ENFANT D'AGE PRESCOLAIRE ; VACCINATION ; DOSE ; TOXICITE ; IMMUNITE ; METHODE D'ANALYSE ; TEST ELISA ; TEST BIOLOGIQUE ; ETUDE EXPERIMENTALE ; ETUDE COMPARATIVE ; MENINGITE ; MEND ; MENPS ; PRP T
Description Géographique
NIGER ; NIAMEY
Localisation
Fonds IRD [F B010026109]
Identifiant IRD
fdi:010026109
Contact